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| 超高效液相色谱三重四级杆质谱联用法测定水中喹诺酮类抗生素 |
| Determination of Quinolones in Water Samples by Solid Phase Extraction-Ultra Performance Liquid Chromatography Electrospray Tandem Mass Spectrometry |
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| DOI： |
| 中文关键词: 喹诺酮类抗生素 固相萃取 超高效液相色谱三重四级杆质谱联用法 水质 |
| 英文关键词: Quinolone SPE UPLC-MS/MS Water quality |
| 基金项目:水体污染控制与治理科技重大专项基金资助项目（2009ZX07313-007）；江苏省环境监测科研基金资助项目（1006） |
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| 中文摘要: |
| 采用固相萃取-超高效液相色谱三重四级杆质谱联用法同时测定水中环丙沙星、氧氟沙星、恩诺沙星、洛美沙星、诺氟沙星等5种喹诺酮类抗生素，优化了前处理和分离检测条件。5种目标化合物在6.5 min内完成分析，在1.00 μg/L～100 μg/L范围内线性良好，方法检出限为0.3 ng/L～1.0 ng/L，空白和实际水样加标回收率为81.5%～116%，平行测定的RSD为6.0%～14.1%。 |
| 英文摘要: |
| A rapid analytical method for simultaneous determination of five quinolones (QNs) including ciprofloxacin,ofloxacin,enrofloxacin,lomefloxacin and norfloxacin in water sample was developed. Under optimizing process of extraction,separation and determination，the five antibiotics were analyzed within 6.5 min. The results showed good linearity ranging from 1.00 μg/L to 100 μg/L,and detection limits of 5 QNs between 0.3 ng/L and 1.0 ng/L. The average recoveries rate of blank and real samples were in the range of 81.5% ～ 116% with the RSDs between 6.0% and 14.1%. |
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