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| HPLC-MS/MS法测定三角帆蚌中多种N-亚硝胺类化合物 |
| Determination of N nitrosamines in Hyriopsis cumingii using High Performance Liquid Chromatography Tandem Mass Spectrometry |
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| DOI： |
| 中文关键词: N-亚硝胺 同位素稀释 基质分散固相萃取 液相色谱-串联质谱法 三角帆蚌 |
| 英文关键词: Nnitrosamines Isotope dilution MSPD HPLC MS/MS Hyriopsis cumingii |
| 基金项目:农业部渔业水域环境污染与生态效益监测基金资助项目（ZX08S322300） |
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| 中文摘要: |
| 采用基质分散固相萃取-同位素稀释-HPLC-MS/MS法同时测定三角帆蚌肉中9种N-亚硝胺类化合物（NAs），通过优化前处理和仪器条件，使方法在5.00 μg/L～200 μg/L范围内线性良好，方法检出限为2.58 μg/kg~8.86 μg/kg。对样品做2个质量比水平的加标回收试验，各组分的平均回收率为78.1%~90.3%，RSD值≤6.8%。将该方法用于测定20个河蚌样品，9种NAs均为未检出。 |
| 英文摘要: |
| A method was developed for the simultaneous determination of nine N nitrosamines in Hyriopsis cumingii samples using matrix solid phase dispersion (MSPD) followed by isotope dilution and high performance liquid chromatography tandem mass spectrometry (HPLC MS/MS). With the optimized sampler pretreatment and instrument parameters, the method had good linearity in the ranger of 5.00 μg/L～200 μg/L. The detection limits were 2.58 μg/kg～8.86 μg/kg. The average recoveries of these compounds ranged from 78.1% to 903% and the RSDs were below 6.8%. Applied this method to 20 Hyriopsis cumingii samples, the 9 N nitrosamines were undetected. |
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